Teenagers Who Smoke Cannabis Damage Their Brains for LIFE and May Be More Likely to Develop Schizophrenia
The Study & Finds
- U.S. study found that mice exposed to even small doses of marijuana for 20 days suffered lasting brain damage in adulthood
- Results highlight how teenagers who regularly smoke weed may have a greater risk of developing schizophrenia
Teenagers who regularly smoke cannabis suffer long-lasting brain damage and are in much greater danger of developing schizophrenia. American researchers say the drug is particularly dangerous for a group of people who have a genetic susceptibility to the mental health disorder – and it could be the trigger for it.
Asaf Keller, of the University of Maryland School of Medicine, said the results highlight the dangers of teenagers smoking cannabis during their formative years.
Previous research has shown that children who started using marijuana before the age of 16 are at greater risk of permanent brain damage, and have a significantly higher incidence of psychiatric disorders.
‘Adolescence is the critical period during which marijuana use can be damaging,’ said the study’s lead author, Sylvina Mullins Raver, a Ph.D. candidate at the University of Maryland School of Medicine.
‘We wanted to identify the biological underpinnings and determine whether there is a real, permanent health risk to marijuana use.’
The scientists began by examining cortical oscillations in mice. Cortical oscillations are patterns of the activity of neurons in the brain and are believed to underlie the brain’s various functions.
These oscillations are very abnormal in schizophrenia and in other psychiatric disorders.
The scientists exposed young mice to very low doses of the active ingredient in marijuana for 20 days and then allowed them to return to their siblings and develop normally.
‘In the adult mice exposed to marijuana ingredients in adolescence, we found that cortical oscillations were grossly altered, and they exhibited impaired cognitive abilities,’ said Raver.
‘We also found impaired cognitive behavioral performance in those mice. The striking finding is that, even though the mice were exposed to very low drug doses, and only for a brief period during adolescence, their brain abnormalities persisted into adulthood.’
The scientists repeated the experiment, this time giving marijuana to adult mice that had never been exposed to the drug before.
According to the research team, there is a group of people who have a genetic susceptibility to developing schizophrenia. Adding weed to the mix during adolescence could be the trigger that causes it to develop, permanently impairing brain function and cognition.
Their cortical oscillations and ability to perform cognitive tasks remained normal, indicating that it was only drug exposure during the critical teenage years that impaired brain activity.
‘We found that the frontal cortex is much more affected by the drugs during adolescence,’ said Keller.
‘This is the area of the brain controls executive functions such as planning and impulse control. It is also the area most affected in schizophrenia.’
Keller now wants to know whether the effects can be reversed. ‘We are hoping we will learn more about schizophrenia and other psychiatric disorders, which are complicated conditions,’ he said.
‘These cognitive symptoms are not affected by medication, but they might be affected by controlling these cortical oscillations.’
There are still many who reject the idea that marijuana is one of the environmental factors that can act on a genetic susceptibility to triggering schizophrenia. Considering the terrible pain of those hit by schizophrenia and their families, I feel we should do everything we can to research this further and if there is a correlation between the two then the public needs to know more so they can make the best-educated choices, so they do not cause themselves unnecessary medical conditions.
What are your thoughts about this?